Permissions
Creating virtual COM ports and opening real serial devices may require administrator permission. Set this up before production use.
Firewall
For TCP Server mode, allow the chosen listen port through Windows Firewall if remote machines need to connect.
Startup behavior
Use the application settings to configure background/startup behavior where appropriate for your workstation policy.
Document the mapping
Keep a record of rule name, COM port, mode, IP address, TCP port, and device purpose.
Diagnostics
Export diagnostics after setup and whenever the environment changes. It gives support a baseline.